2+ day, 19+ hour ago   (465+ words) Epidermal growth factor receptors (EGFR) are supposed to help your cells grow and divide. When this gene mutates, it can get stuck producing new cells, leading to abnormal cell growth, otherwise known as cancer. It’s a significant risk factor for…...

4+ day, 1+ hour ago   (292+ words) When a patient with decision-making capacity declines immediate excision of a lesion on her foot despite strong suspicion of acral melanoma, the appropriate response is to balance the patient’s autonomy with the clinician’s duty to act on the suspected malignancy,…...

4+ day, 2+ hour ago   (282+ words) Home removal of indwelling urinary catheters by patients on day 1 after urogynecologic surgery was noninferior to standard removal on postoperative day 3 or 4 in terms of ongoing urinary retention rates, according to a single-institution study published in the American Journal of…...

4+ day, 6+ hour ago   (273+ words) Investigators reviewed observational studies evaluating the association between APOL1 risk variants and renal outcomes in patients with SLE. The analysis included four studies comprising 1,885 patients of African ancestry, including 321 individuals with high-risk APOL1 genotypes and 1,564 with low-risk variants. Across the pooled dataset,…...

4+ day, 14+ hour ago   (600+ words) The medication didn’t work.” Nearly every clinician who manages chronic disease has heard some version of this statement. Sometimes treatment truly fails. Sometimes disease progresses despite appropriate therapy. But often the issue is more subtle: a gap between what the…...

1+ week, 13+ hour ago   (82+ words) This content was created in collaboration with AbbVie. Giant cell arteritis demands rapid treatment while balancing the long-term risks of sustained steroid use. Upadacitinib offers a steroid-sparing approach, making careful patient selection and shared decision-making central to care. Stay tuned…...

1+ week, 17+ hour ago   (96+ words) Paras Karmacharya, MD, MS This content was created in collaboration with AbbVie. Paras Karmacharya, MD, discusses how switching treatment mechanisms after initial therapy failure significantly improved low disease activity and remission rates versus cycling therapies at 12 weeks. Despite these gains,…...

1+ week, 3+ day ago   (536+ words) Physician's Weekly Q&A: Neighborhood Social Vulnerability Influences Colon Cancer Trial Enrollment for Younger Patients Young adults with colon cancer demonstrated higher enrollment in clinical trials, but their odds of enrollment were more negatively influenced by neighborhood social vulnerability compared with…...

1+ week, 4+ day ago   (655+ words) In their broad overview, the researchers explain how optimized tissue handling, appropriate test selection, and interdisciplinary collaboration can improve outcomes for patients with NSCLC, which accounts for almost 85% of all lung cancer cases. Physician’s Weekly spoke with Michael Grant, MD,…...

1+ week, 4+ day ago   (174+ words) Patient-Level Factors Drive Treatment Intensification Decisions in De Novo mHSPC In the complete cohort, most of the variation in treatment intensification was attributable to patient characteristics. Patients who were older had lower odds of intensification, as did patients who were…...