3+ day, 16+ hour ago   (641+ words) By Jonathan D. Grinstein, PhD Could an academic laboratory build genetic medicines for diseases the traditional drug-development model leaves behind? Sena-Esteves sees that mismatch repeatedly. “I wish it wasn’t that way—that we had plenty of money and could just work…...

4+ day, 18+ hour ago   (318+ words) An analysis of nearly 1000 prostate tumor samples has revealed eight integrated mutational footprints (IMFs) that underpin the majority of genetic alterations found in prostate cancer genomes, some of which reflect clinical outcomes. Although prostate cancer has a high prevalence, the…...

4+ day, 19+ hour ago   (829+ words) Helicobacter pylori, the stomach bacterium best known for its role in gastric cancer, may also contribute to colorectal cancer (CRC), according to a new global analysis that estimates the infection could be related to as many as 22% of CRC cases…...

5+ day, 20+ hour ago   (340+ words) Genetic variants commonly found in people of European descent are associated with accelerated progression of Parkinson’s disease (PD), research indicates. The findings, in JAMA Neurology, suggest common loss-of-function variants in the melanocortin 1 receptor (MC1R) gene, carried by more than 60% of individuals…...

1+ week, 2+ day ago   (450+ words) Reactive oxygen species are usually cast as the villains in cancer, capable of damaging DNA and promoting tumor growth. But new research shows that cancer-fighting T cells need small amounts of these molecules—and tumors may exploit that dependence to…...

1+ week, 4+ day ago   (763+ words) The genetic mechanism driving an oncogene could help determine whether a tumor responds to protein-degrading therapies, potentially providing a new consideration for selecting patients for this emerging class of cancer drugs. The results suggest that tumors in which an oncogene…...

1+ week, 5+ day ago   (443+ words) Two recent clinical readouts highlight both the promise and limitations of therapeutic cancer vaccines. The divergent outcomes sharpen a key question for the field: Is generating tumor-specific immunity enough, or must cancer vaccines also create conditions in which that immunity…...

1+ week, 6+ day ago   (463+ words) Researchers have developed a new way to detect small decreases in proteins inside living cells, creating an amplified signal that could make it easier to discover drugs that eliminate disease-causing proteins. The approach, called ratiometric transcriptional activation (RTA), converts the…...

1+ week, 6+ day ago   (424+ words) Heart failure has no shortage of effective drugs. The bigger problem is getting patients onto them. A new Nature Medicine study takes a precision medicine approach to that problem. Researchers pooled individual-level data from 38,753 participants across nine major randomized heart…...