3+ day, 15+ hour ago   (361+ words) Inside Precision Medicine Surbhi Jain, PhD, MBBS Surbhi Jain, PhD, MBBS, is a staff scientist at Bio-Rad Laboratories and the R&D lead for the ddPLEX EGFR/KRAS/BRAF multiplexed droplet digital PCR panel. She is focused on developing ddPCR…...

3+ day, 15+ hour ago   (641+ words) By Jonathan D. Grinstein, PhD Could an academic laboratory build genetic medicines for diseases the traditional drug-development model leaves behind? Sena-Esteves sees that mismatch repeatedly. “I wish it wasn’t that way—that we had plenty of money and could just work…...

3+ day, 20+ hour ago   (322+ words) Scientists have found that certain chemotherapy drugs can age children’s healthy cells, causing the same amount of DNA damage in a short period that would normally accumulate over decades in middle-aged adults. Results published today in Science uncover the extent…...

4+ day, 17+ hour ago   (318+ words) An analysis of nearly 1000 prostate tumor samples has revealed eight integrated mutational footprints (IMFs) that underpin the majority of genetic alterations found in prostate cancer genomes, some of which reflect clinical outcomes. Although prostate cancer has a high prevalence, the…...

4+ day, 21+ hour ago   (474+ words) A comprehensive genomic profiling study involving more than 13,000 patients has shown that targetable G12C mutations in the KRAS oncogene are rare in genitourinary cancers, potentially limiting the role of routine testing and targeted treatment in these malignancies. KRAS G12C accounts for approximately…...

4+ day, 21+ hour ago   (321+ words) European researchers have proposed a biomarker-based treatment algorithm for patients with mantle cell lymphoma that could move treatment decisions beyond age and transplant eligibility toward individualized strategies based on disease biology and treatment response. The call for a change to…...

1+ week, 4+ day ago   (469+ words) A new type of proton beam radiation therapy known as FLASH proton therapy is being tested in a Phase I trial in patients with relapsed head and neck cancer who are not eligible for surgery at the Perelman School of…...

1+ week, 6+ day ago   (463+ words) Researchers have developed a new way to detect small decreases in proteins inside living cells, creating an amplified signal that could make it easier to discover drugs that eliminate disease-causing proteins. The approach, called ratiometric transcriptional activation (RTA), converts the…...

2+ week, 4+ day ago   (435+ words) Research from the Karolinska Institute in Sweden shows assessing whether breast cancer tumors are estrogen receptor (ER) positive or not is more accurately measured as a spectrum rather than just classifying them as positive or negative. The researchers used a…...

2+ week, 4+ day ago   (742+ words) A new cancer immunotherapy strategy aims to turn an abundant laboratory-grown cell source into a personalized teacher for the immune system—showing a patient’s T cells not just one tumor target, but potentially the full array of targets displayed by…...